When is the best time to take Letrozole tablets?
Letrozole tablets are a drug commonly used to treat breast cancer and are aromatase inhibitors. The correct time of taking is crucial for the drug to be effective and reduce side effects. The following is a detailed analysis of the taking time of letrozole tablets, combined with hot medical topics and frequently asked questions from patients on the Internet in the past 10 days.
1. Basic information about letrozole tablets

Letrozole tablets are mainly used to treat hormone receptor-positive breast cancer in postmenopausal women by inhibiting aromatase to reduce estrogen levels. Here are its key figures:
| Drug name | Letrozole |
| Indications | Adjuvant treatment of breast cancer in postmenopausal women/advanced breast cancer |
| Common dosage | 2.5mg/day |
| half life | about 48 hours |
2. Suggestions on the best taking time
According to clinical research and doctor’s recommendations, the following points should be noted when taking letrozole tablets:
| time point | Reason |
| Fixed time every day (such as morning) | Keep blood drug concentration stable and avoid missing doses |
| Can be taken after meals or on an empty stomach | Food does not affect absorption, but people with sensitive stomachs are advised to take it after meals |
| Avoid taking it at night | Reduce possible side effects of dizziness or hot flashes that interfere with sleep |
3. Time interval with other drugs
If combined medication is required, the following intervals should be noted:
| combination drugs | Recommended interval |
| Calcium/vitamin D | ≥2 hours (letrozole may affect calcium absorption) |
| estrogen drugs | Simultaneous use prohibited |
| CYP3A4 inhibitors (such as erythromycin) | Consult your doctor to adjust dosage |
4. Answers to Frequently Asked Questions by Patients
1. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember; if it is close to the next dose time, skip this dose and do not double the dose.
2. Precautions for long-term use
Bone density (letrozole may increase the risk of osteoporosis) and blood lipid levels need to be monitored regularly.
3. Medication withdrawal time
Usually adjuvant treatment lasts for 5 years, but it needs to be adjusted according to the condition and doctor's recommendations.
5. Correlation of hot topics across the entire network
In the past 10 days, discussions related to breast cancer treatment have focused on "drug compliance" and "side effect management." For example:
Summary
The best time to take Letrozole tablets is in the morning at a fixed time every day, either after meals or on an empty stomach. Patients need to strictly follow medical advice, pay attention to drug interactions and long-term monitoring to ensure maximum treatment effect.
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